Radium-223 derived from proton irradiated Thorium is the first alpha-emitting isotope that obtained Food and Drug Administration approval for the treatment of cancer. 2I3Bismuth is a decay product of 225Ac (t1/2 = 10.0 d), itself an alpha emitter. Currently the domestically-produced supply of 225Ac, however, is limited by the availability of the parent radionuclide, 229Th, derived from U233, all of which is currently being destroyed by down blending.
References:
- https://www.energy.gov/science/np/articles/thorium-source-multiple-medical-isotopes
- https://pubs.acs.org/doi/abs/10.1021/bk-2004-0868.ch013